Summary Air-driven Microfluidizer

Quetion: Describe about air-driven microfluidizer? Answer: The operating efficiency of an air-driven microfluidizer, which is the bench top type, has been compared to the high power ultrasonic horn, which also is the bench top type, using a model drug, aspirin, for production of pharmaceutical grade nanoemulsions. This has been done by considering various factors like the chemicals and reagents, the pre-homogenization preparation of coarse emulsion, emulsification using ultrasonication, emulsification using microfluidization, polydispersity index analysis and emulsion droplet size and, viscosity determination, pH stability analysis, field emission scanning electron microscopy and the statistical analysis of these factors. The drug loading and prehomogenizations influence on the resultant mean droplet diameter and distribution of size of the droplets that have been emulsed, has been studied. This study has been done in an oil-in-water nanoemulsion. This has again been incorporated with the aspirin as the model drug. The results has been studi ed. This has been done on the factors depending on effect of energy input of microfluidization and ultrasonication on the properties of the resultant emulsion, number of passes using microfluidizer and effect of operating pressure , effect of time of irradiation using ultrasound and power amplitude, the influence of pre-homogenization on the properties of sonicated emulsion and microfluidized, influence of drug loading on the properties of generated emulsion using microfluidizer and sonication, the pH influence on the stability of generated emulsion using sonication and microfluidizer. It has been observed for the microfluidizer, that the size of the emulsion droplets was almost independent of the number of passes and applied microfluidization pressure. Thus, ultrasound cavitation is highly energy efficient and effective pharmaceutical nanoemulsions. References S. Hatziantoniou, G. Deli, Y. Nikas, C. Demetzos, G.T. Papaioannou, Scanning electron microscopy study on nanoemulsions and solid lipid nanoparticles containing high amounts of ceramides, Micron 38 (8) (2007) 819823.P. Becher, Emulsions Theory and Practice, second ed., Reinhold Publishing Corp., New York, 1965.